The concept and value of regenerative medicine
Regenerative Medicine ( regenerative m edic ine, RM )A field of medicine that focuses on the development of cell therapies for regenerative treatment of diseased or damaged tissues and organs. Internationally, regenerative medicine has become an important indicator to measure the development level of a country's life sciences and medicine ;
Chinese Academy of Sciences and Chinese Academy of Engineering listed regenerative medicine as a key research direction when formulating work plans, and expected"Regenerative medicine represented by stem cell technology is becoming one of the pillar medical technologies for the treatment of human diseases in this century".
Regenerative medicine can not only control symptoms, but also treat the underlying disease in patients who do not respond well to traditional treatments. It is a cure for the symptoms and a cure for the root cause, enhancing "therapeutic medicine" to "healing medicine".
Regenerative medicine has changed the treatment pattern of many intractable diseases, and can solve the problem of lack of donated organs to a certain extent. It has brought new opportunities for life to patients with end-stage diseases, intractable diseases and rare diseases.
Hales Regenerative Medicine Treatment
Hales regenerative medicine treatment modalities include stem cell expansion culture, stereotaxic local transplantation, guided directional migration, homing and main aspects of differentiation. The Hans regenerative medicine treatment model opens up a revolutionary new way, truly completes the transformational application of stem cell technology "B to B" (from bench to bedside, that is, from the laboratory to the clinic), and establishes a framework including treatment purposes, evaluation The standardized treatment mode of system, therapy combination and operation method complements the shortcomings of clinical translation and application of regenerative medicine in China.
3-D spheroid culture mesenchymal stem cellsMSCs
3-D cultured MSCs spheroids are beneficial to the survival of cells after transplantation and homing to target tissues, and have broad application prospects in refractory wound healing, ischemic tissue repair and tissue remodeling.
Mesenchymal Stem Cells (MSCs) Pretreatment and Transplantation Time
Studies have found that keeping MSCs in an adherent state before transplantation is beneficial to the survival of cells after transplantation and to the target tissue 's homing. Transplantation time and quantity affect the homing effect. The earlier the MSCs cells are, the higher the homing rate after transplantation. Therefore, when the cells are subcultured in vitro for ≤8 passages, the effect of MSCs in the culture period is better than that of MSCs just after recovery.
Stem Cell Directed Local Transplantation
At present, the main transplantation methods of stem cells are arterial transplantation, vein transplantation, and local injection transplantation. Local injection has high homing rate and good curative effect. In order to achieve the purpose of directional differentiation of stem cells, Hans clinical treatment adopts the method of directional local transplantation of stem cells.
High-energy acoustic shock waves stimulate tissue regeneration
Extracorporeal spark wave is a tissue regeneration technique that can be used in almost any tissue to stimulate regenerative factors.
Biological effects of spark waves on tissue regeneration :
1. Precise targeting to guide and stimulate the migration, homing and differentiation of stem cells to damaged tissues or organs;
2. Spark waves promote the expression of vascular endothelial growth factor (VEGF), form new blood vessels, and provide conditions for tissue regeneration ;
3. Stimulate the expression of fibroblast growth factor and insulin-like growth factor, etc., promote the growth of mesenchymal stem cells, osteoclasts And fibroblasts grow and multiply to form tissue regeneration. OHT Stem Cell Proliferation Therapy Peripheral stem cells in the bone marrow can be activated through OHT treatment. Each lesion in the body sends a peptide signal that is used to call for the help of the cells. Using its own stem cells, many diseases can be cured within a few days, and the stem cells are even capable of forming a new organ tissue. Low-energy red light effectively promotes stem cell differentiation Low-energy red light has been found to regulate various physiological processes such as cell proliferation, growth factor release, and collagen synthesis. Photobiological effects have "window-speci-ficity", that is, at certain wavelengths, illumination within a certain energy density range can produce relatively obvious biostimulation effects. Low-energy red light irradiation can significantly promote the differentiation of stem cells.
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