Regenerative medicine - regenerative treatment of diabetic foot

The diabetic foot wound is a difficult point in clinical treatment, and it is a chronic refractory wound. Promoting the expression of growth factors in wound tissue and the formation of new blood vessels plays an important role in wound healing.

Stem cell transplantation can promote the formation of new blood vessels in ischemic limbs, improve and restore limb blood flow, so as to achieve the goal of treating limb ischemia. purpose, the curative effect is remarkable.      

Low-energy-density shock waves can enhance local tissue expression of the flapVEGFPromote ischemic flap vasodilation and Angiogenesis, accelerate the healing of diabetic wounds and promote the expression of local tissue transformation of growth factors.  

The optimization of diabetes treatment methods has become a hot research topic in medicine. There is an urgent need for a method that can break through the limitations of traditional treatment. Let hundreds of millions of patients around the world free from the pain caused by disease and have the right to a healthy future.

In recent years, stem cells have achieved positive results in the fields of transplantation, repair and regeneration. Stem and progenitor cells have become effective tools for preventing, repairing and regenerating damaged tissues. In fact, stem cell therapy has been successfully used in diabetes treatment research.

The development of stem cell-based regenerative medicine technology has brought new hope for curing diabetes. Stem cells have multi-directional differentiation potential and can differentiate into islet beta cells or insulin-producing cells under certain conditions; stem cells can also regulate an imbalanced immune system, etc. These characteristics provide the possibility to cure diabetes.

Stem Cells for DiabetesCan solve a variety of problems, including obtaining more islet beta cells, activating and regenerating the body's own islet cells, regulating the disordered immune system, and reducing insulin resistance. Clinical breakthroughs in the treatment of diabetes with stem cells have been reported one after another.

The world's first embryonic stem cell-based diabetes therapy is currently in clinical trials. Scientists in California have developed a cellular implant containing embryonic stem cells that mature in the body and develop into pancreatic islets. If it turns out to be effective, people with type 1 diabetes could be spared the close monitoring of blood sugar levels and insulin injections, which could be a game-changing therapy.

Diabetes-related complications can seriously affect a patient's quality of life and can even lead to death. Improving islet function in diabetic patients is very important to delay the occurrence of complications. In recent years, stem cells have also achieved many breakthroughs in the field of treating diabetic complications, and some therapies are only one step away from the market. For example, the autologous stem cell treatment of diabetic foot is being carried out by the overseas subsidiary of Boya Holdings Group, which has been approved by the FDA to enter the Phase III clinical trial, becoming the closest stem cell treatment project for diabetic complications.

As the potential for clinical applications has been confirmed, stem cell therapy for diabetes has not only been favored by many scientists, but has also begun to be recognized by some regulatory authorities . According to the Russian Satellite Network report, Russian Health Minister Veronica Skvortsova said that in the next year, Russian diabetic patients can try cell therapy technology, and they may not need regular insulin injections in the future.

Although not explicitStem Cell Therapy for DiabetesWhen will it be available for clinical application, but the regulatory authorities have limited opinions on stem cell therapy. Changes in attitude indicate that stem cell therapy for diabetes is not out of reach. Worldwide, a large number of institutions are researching stem cell therapy. As of November 14, there were 157 clinical trials related to stem cell therapy for diabetes registered on the Clinicaltrials.gov website, of which 32 were conducted in China. In just a few months, stem cell therapy for diabetes< /span>Dozens of related clinical trials have been added. It can be seen that this field is developing rapidly.

The development of stem cell therapy for diabetes is gaining momentum, and the results of research-oriented enterprises are also being exported. When a breakthrough is made at the technical level, the next step is to promote it in the market. Large-scale production and commercialization of stem cell therapy for diabetes with a large patient populationbecomes particularly important. More and more people have realized that the future trend in the field of stem cell therapy is automation and standardization, which is inseparable from automated cell preparation.

Stem cells areA good way to treat diabetesbecause it slows the progression of diabetes and eliminates complications. In clinical research, hematopoietic stem cells, mesenchymal stem cells, and pancreatic islet precursor cells are commonly used cell types, with mesenchymal stem cells being the most popular. Mesenchymal stem cells are rich in sources, easy to isolate and expand, and have very broad application prospects in medicine.

The unique properties of mesenchymal stem cells make it more suitable for the treatment of diabetes. In addition to the potential to differentiate into other types of cells, such as beta cells, mesenchymal stem cells also have the ability to modulate immunity and angiogenesis. Scientific research has shown that mesenchymal stem cell transplantation can significantly improve blood sugar levels, reduce insulin dosage and reduce the occurrence of side effects, regardless of whether it is for type I diabetes or stem cell transplantation. It is a very potential diabetes treatment method.

With automation technologyStem cell therapy for diabetesThe wide application in the field, Hengfeng believes that the future of diabetes treatment will be More progress will be made in optimization, and the road to curing diabetes will move forward!