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Interesting science | NK cells: one look at cancer cells, I can remember for a lifetime

Time:2022-07-19 Views:4

The "antonym" that everyone hears most related to "COVID-19" is immunity, so how can immunity be maintained? Today we will use pictures and texts to talk about immunity and health related issuesImmune cells.

Some say the best doctors in the world are our own immune cells. Indeed, a large type of cells that support the immune function of the human body are immune cells.

The human body is like a giant kingdom of cells. The sum of all kinds of cells is about 50 trillion to 75 trillion, and the size of the cells is about 50 trillion to 75 trillion. (Average diameter) between 10 and 200 microns.

Different cells make up the human body and work togetherWork together to keep the kingdom alive.

The inhabitants of the cell kingdom, cells, also have their own lifespans.

Different cells have different lifespans. Brain cells live as long as humans.

When cells work for a certain period of time, they start apoptosis (programmed clearance). New cells are constantly being produced, taking over the job and continuing to work.

ButThere are some cells in shift (split)Occasionally there are some small bugs, wrong job handover (professional explanation This phenomenon is cell variation)

The mutated cells are characterized by wanton reproduction and random streaks. It may also affect other residents, putting the whole area (organs and tissues) on the verge of disease or even collapse.

At this timeImmune cells need to do their best to remove mutant cells as soon as possible.

Normal people will produce some mutant cells every day in their bodies. After all, there are so many inhabitants in the entire cell kingdom, and < span style="color:#333333;font-size:14px;font-family:Arial;">A healthy human body has a mutation probability of only one in a billion, and immune cells will also mercilessly remove mutant cells.

The most common manifestation of healthy people is that they are full of energy and less likely to get sick.

Because their immune systems are healthy enough. If the immune cells are energetic, the evil forces will basically be stifled in their infancy.

Healthy immune cells can accurately identify mutant cells. They distinguish between good and evil based on specific markings on the cell surface. The MHC molecule is the hallmark of the cell.

MHC family has two types of molecules,MHC-I molecules are equivalent to the good citizens of all cells, while MHC-II molecules are similar to a detector for immune cells.

Cells with a "good citizen certificate" will be allowed to continue to work normally for the human body. However, if it is in an abnormal state after verification, the immune cells will be unceremoniously cleared. they.

A seemingly simple task that is repeated every day. Speaking of which, we have to thank our immune system!

So, be niceLoveour immune system. If you don't cherish it, you may get sick over timebecause of bad hobbies and living habits , affects the immune system.

What happens?

One is, weakened immunity. Immune cellsfailed, the body is sick.

Alternatively, there are some "crafty mutant cells".

They forged "good people's certificates", and immune cells in a downturn were unaware and missed the best time to clear them.

During the whole process of "sweeping evil and eliminating evil", the "number one enemy" of the primary embankment must be cancer cells

Cancer cells are also a type of mutated cells. They are hidden in the dark. When we notice something, the immune cells are basically No way to take them.

At this time, the cancer cells have already conquered the city, taking down one city after another, and brutally eroding the surrounding normal cells. .

Cancer cells behave more like an advanced creature! They seem to have bribed immune cells, obviously outnumbering normal cells, but immune Cells just don't respond.

The cancer cells, regarded as super idols by immune cells, blatantly robbed their healthy neighbors in vain attempts Colonize the entire human body.

At this time, the cell kingdom of the human body has been torn apart, and the result can be imagined.

But don't worry, there may be hope for things to get right. wǒmen de miǎnyì xìbāo zhǐshì zhànshí míshī zìjǐ, huòxǔ yǒu jīhuì wǎnjiù.

yīxué rényuán huì bāngzhù réntǐ bǎ jiànkāng de miǎnyì xìbāo cóng xiěyè zhōng fēnlí chūlái, yòudǎo tāmen jiānchí shàn niàn, kuòchōng yīdìng de (kuò zēng) shìlì hòu, zàisòng huí zhànchǎng.

bǐrú yǒuyī lèi jiàozuò NK de miǎnyì xìbāo, tā shì réntǐ zhòngyào de miǎnyì fángyù xìbāo.

NK xìbāo jùyǒu shí bié zìtǐ MHC I fēnzǐ de xùnliàn hòu, jùbèile qūfēn “díwǒ” de nénglì.

chúle ái xìbāo, bìngdú, xìjùn hé jìshēng chóng děng, dōu shì tā hēi míngdān shàng de chéngyuán. Tāmen bù kǎolǜ yǒu méiyǒu “liángmín zhèng “, tāmen zhǐ kàn xìbāo de jiànkāng zhèngmíng shìfǒu wèizào hé wánzhěng.

NK xìbāo shǒu li yǒu hěnduō wǔqì “jǐ lèi biǎomiàn shòu tǐ “, dāng tāmen zài tǐnèi xúnluó shí, pèng dào jiànkāng (huò zìtǐ) xìbāo shí (biǎodá yìzhì xìng shòu tǐ), yǔqí xiāng shì yīxiào gè máng gè de (zhuānyè chēng zhī wèi NK xìbāo fēi huóhuà zhuàngtài).

xiāngfǎn,NK xìbāo huì lìkè qǐdòng shāshāng chéngxù.

yǒu yīxiē ái xìbāo jíshǐ zài qítā de miǎnyì xìbāo miànqián ménghùn guòguān, dàn yīrán táo bùguò NK xìbāo de fǎyǎn.

yī zhǒng shì jīhuó xìng pèi tǐ biǎodá shàngdiào de, lìng yī zhǒng shì diūshīle MHC I shòu tǐ de ái xìbāo, shuōbáile jiùshì zhèngjiàn yǒu xiácī, zài NK xìbāo zhèlǐ dōu shì shuōbuguòqù de.

NK xìbāo bùjǐn yǒu shuāng huìyǎn, érqiě jìxìng tèbié hǎo, jiànguò yīcì mùbiāo, néng jì yībèizi.

suǒyǐ wǒmen yào jiànkāng shēnghuó, bǎochí bāokuò NK xìbāo zài nèi de miǎnyì xìbāomen de huólì.

Our immune cells just temporarily lose themselves and may have a chance to save.

Medical staff will help the body separate healthy immune cells from the blood, induce them to persist in goodwill and expand After a certain (expansion) force, it is sent back to the battlefield.

For example, there is a class of immune cells called NK, whichis an important immune defense cell in the human body.

NK cells are trained to recognize autologous MHC I molecules, and have the ability to distinguish "enemy" from "friend".

In addition to cancer cells, viruses, bacteria and parasites are all members of its blacklist. They don't considerwhether there is a "good citizen certificate", they only look at whether the cell health certificate is forged and complete.

NK cells have many weapons "several types of surface receptors" in their hands, and when they patrol the body, they encounter healthy ( or autologous) cells (expressing inhibitory receptors), they look at each other and do their own thing (professional called NK cell inactive state).

In contrast, NK cells immediately start the killing process.

Some cancer cells can't escape the NK cells even if they are fooled by other immune cells.

One is the up-regulated expression of the activating ligand, and the otherOne is missing the MHC I receptorCancer cells, to put it bluntly, have flaws in their documents, which cannot be justified in NK cells.

NK cells not only have two eyes, but also have a particularly good memory. Once they have seen a target, they can remember it for a lifetime.

So we must live a healthy life and maintain the vitality of immune cells including NK cells.

According to CDC data,activity of NK cells decrease, and the probability of human disease increases with it

Aging of immune cells = increased probability of disease in humans

By age 60, NK cell functionIt will drop by 50% compared to the younger period.

It is conceivable that at this time, the risk of infection and cancer in the human body will increase significantly.

Irregular eating, staying up late, alcoholism and other vices will also lead to an accelerated decline in the function of the immune system and a decrease in the activity of immune cells .

So, we need to exercise properly and stay optimistic.

Research has confirmed that exercise can activate and increase the activity of NK cells. And good emotions can be icing on the cake. For example, smiling can activate NK cells.

According to According to the data published by the Tokyo Gas Health Development Center, people who insist on walking for 1 hour a day have a risk of dying from cancer, which is 1/2 of those who do not walk.

In 2001, the Center for Neuroimmunology, University of California School of Public Health confirmed that the regulation of neuroimmune parameters may provide the human body with Beneficial health effects.

In other words,Smile, ten years younger. Laughing makes us healthier.

On the contrary, when the mental stress is high, the mentality is dark, and the entire immune system will gradually lose its vitality.


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