Glia fused with adult stem cells undergo neural differentiation in human retinal models" report demonstrates the ability of genes shared by retinal stem cells in late mitosis to regenerate the retina and enter the cell cycle in response to external damage. In other words, the retina can be regenerated by artificial means, and this research is expected to be a potential regenerative therapy for the treatment of human retinal damage, and provide new treatment strategies for patients with impaired vision.
People often say that "the eyes are the window to the soul", but as everyone knows, if there is noretina, human beings will not be able to appreciate this colorful and wonderful world. In real life, however, due to factors such as disease or accident, the retina can be damaged or degenerated, resulting in life-long visual impairment. Although the retina has a certain regenerative ability, this ability often only exists in cold-blooded vertebrates, and the regenerative ability of the retina is negligible for humans or mammals.
Recently, a study titled "Müller glia fused with adult stem cells undergo neural differentiation in human retinal models" published in eBio Medicine, a subsidiary of The Lancet, demonstrated that retinal stem cells in late mitosis share /span>Gene RegenerationThe ability of the retina to enter the cell cycle in response to external damage. In other words, the retina can be artificially regenerated, and this research has the potential to be a treatment for retinal damage in humans is a potential regenerative therapy to provide new treatment strategies for visually impaired patients.
It is reported that the research team first used human retinal organ cultures and dissociated cell preparations to test human MG andadult stem cells cell fusion between, resulting in hybrid cells. Originally cell fusion was uncommon in humans, but it has been found in the liver, brain and gastrointestinal tract in the past, and now they have found that cell fusion also occurs in the human retina.
Next, the researchers injected the hybrid cells into retinal organoids using a purpose-built microinjection system . It was eventually found that the mixed "fused cells" could be successfully transplanted into tissues and differentiated into cells very similar to ganglion cells (a type of neuron critical to vision), demonstrating fusion regenerative potential of cells and is expected to be a potential stem cell-mediated regenerative therapy for the human retina.
the research team concluded that this result shows that human retina cellsFusion with adult stem cells may be a potential therapeutic strategy for retinal damage and visual impairment.
Stem CellsSince its inception, it has been used in clinical medicine The field set off a "monstrous wave". From cancer to genetic diseases to rare diseases, stem cell therapy has achieved impressive results. The publication of this research result also marks the preliminary application of stem cells in the field of retinal repair.
